Endocrine Abstracts

Metastasis to bone occurs frequently in advanced breast cancer and is accompanied by debilitating skeletal complications. Parathyroid hormone-related protein (PTHrP) occurs in a high proportion of breast cancer and is strongly implicated in their metastatic spread to bone. Overexpression of PTHRP and its receptor in breast tumour cells could also promote the growth in an autocrine fashion. Signal transduction of growth factor receptor, EGFR (ErbB1, HER1) and ErbB2 (Neu, HER2) ...

PTHrP has been shown to be the primary factor responsible for humoral hypercalcemia of malignancy, and recently PTHrP has been shown to be an early-response gene that may be involved in cellular proliferation or differentiation. 1,25 DHCC and its analoge EB1089 have been reported to inhibits growth of cells derived from a variety of tumours in vitro and in vivo. We have investigated in this study the effect of different 1,25 DHCC and EB1089 doses (from 10&#8...

Nitric Oxide (NO) has been considered a very important molecule in the biological system because of its interaction with other molecules for mediating various bio-pathways. Its interaction with vitamin D in particular studied well in animal models, cell lines and patients with various diseases. However, the relationship between NO and vitamin D has never been studied in healthy adolescents. We aimed to determine the association of NO with vitamin D and other serological factor...

Hypovitaminosis D is associated with an increased prevalence of diabetes mellitus type 2 (DMT2) and the metabolic syndrome. The purpose of this study was to examine the association between 25-hydroxy-vitamin D (25-OH-VitD) levels and adipocytokines and other indices of insulin resistance in a Saudi population with DMT2. One-hundred and fifty-five male and female Saudi adults aged 26–80 were randomly selected from the existing Biomarkers Screening in Riyadh Program (RIYADH...

We studied the association between RBP4 and various markers related to insulin resistance and diabetic complications as well as inflammatory markers in Saudi population suffering from type 2 diabetes and coronary heart disease. Patients with type 2 diabetes were divided into 3 groups according to the type of treatment and involvement of coronary artery disease. Serum TNF-α, insulin, CRP, resistin, leptin and adiponectin were analysed in all samples. RBP4 plasma levels inc...

Background: Previous genome wide association studies in Caucasian and South Asian populations have identified over 35 loci for type 2 diabetes mellitus (T2DM) risk. However, little is known about the contribution of these loci in T2DM from a Saudi Arabian population. In this study we investigated for the first time, the association of 38 previously identified T2DM risk loci (32 loci from Caucasian and six loci from South Asian populations) in 1166 T2DM patients and 1235 health...

Objective: Vitamin D deficiency is associated with an increased risk of type two diabetes mellitus (T2DM) and cardiovascular disease reduced through Vitamin D3 supplementation. However to the best of our knowledge, no research has determined the effect of vitamin D3 supplementation in conjunction with existing pharmacological and non-pharmacological approaches to the DMT2 population. Hence, the aim of this study was to determine the effect of vitamin D3 supplementation in a co...

Introduction: The endoplasmic reticulum enzyme glucose-6-phosphatase catalyzes the common terminal reaction in the gluconeogenic and glycogenolytic pathways and plays a central role in glucose homeostasis. In most mammals, different G6PC subunits are encoded by three paralogous genes (G6PC, G6PC2, and G6PC3). Mutations in G6PC and G6PC3 are responsible for human Mendelian diseases, whereas variants in G6PC2 are associated with fasting glucose (FG) levels.<p class="abstext"...